Mass Balance Study of [14C] D-1553 in Chinese Healthy Adult Male Subjects
Status:
COMPLETED
Trial end date:
2024-01-10
Target enrollment:
Participant gender:
Summary
* To quantitatively analyze the total radioactivity (TRA) in excrement after a single oral dose of \[14C\] D-1553 in healthy subjects, and obtain radioactivity recovery and primary excretion pathways in humans;
* To obtain radioactive metabolite profiles of human plasma, urine and feces , identify major metabolites of D-1553 and determine the major metabolic pathways and elimination pathways;
* To quantitatively analyze the TRA in whole blood and plasma and obtain PK parameters of plasma TRA and investigate whole blood/plasma ratio for TRA.